Validation of Computational Approaches for Antiretroviral Dose Optimization

Computational investigation of simple memetic approaches for continuous global optimization

Computational Approaches for Microalgal Biofuel Optimization: A Review

The increased demand and consumption of fossil fuels have raised interest in finding renewable energy sources throughout the globe. Much focus has been placed on optimizing microorganisms and primarily microalgae, to efficiently produce compounds that can substitute for fossil fuels. However, the path to achieving economic feasibility is likely to require strain optimization through using avail...

Computational Approaches to Simulation and Optimization of Global Aircraft Trajectories

This study examines three possible approaches to improving the speed in generating wind-optimal routes for air traffic at the national or global level. They are: (a) using the resources of a supercomputer, (b) running the computations on multiple commercially available computers and (c) implementing those same algorithms into NASA’s Future ATM Concepts Evaluation Tool (FACET) and compares those...

Backbone switch to abacavir/lamivudine fixed-dose combination: implications for antiretroviral therapy optimization.

Current guidelines recommend treatment optimization in virologically suppressed patients through switching/ simplification strategies to minimize long-term toxicities and improve adherence. The assessment of inflammation/ coagulation profiles may support therapeutic decisions. We undertook a prospective, non-randomized study to evaluate the efficacy and safety of switching to ABC/3TC from ZDV/3...

Optimization Approaches for Generalization

Generalization is needed in order to represent relevant information on an appropriate level of detail. As only a restricted amount of data can be represented on a certain level of detail, different pieces of information have to 'fight' for their representation on a specific aggregation level. This implies that generalization, especially displacement, is an optimization problem, where different ...